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In addition, detailed studies of replication initiation have focused on a limited number of model systems. The extensively studied fungi and metazoa are both members of the opisthokont supergroup and exemplify only a small fraction of the evolutionary landscape in the eukaryotic domain.[195] Comparably few efforts have been directed at other eukaryotic model systems, such as kinetoplastids or tetrahymena.[196][197][198][199][200][201][202] Surprisingly, these studies have revealed interesting differences both in origin properties and in initiator composition compared to yeast and metazoans.[2]

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